In accordance to a news source from San Francisco dated March 12, 2009, a randomized clinical trial has managed to heal cold sores more than a day faster when treated with an investigational nanoparticle emulsion that disrupts the viral membrane. Such news is great to many cold sore sufferers. It is a new break through to remedies for cold sores. Various remedies for cold sores are found in the net and continual improvements to these remedies are always welcome to many.
The news from the American Academy of Dermatology meeting said that when using the topical NB-001 on cold sore patients who are in the prodomal stage of a herpes labialis recurrence, it would speeds up the healing by almost two full days. Such news was great, as the mental stress brought by cold sores is unmeasurable especially when one got to got to face the public. The stigma of being labled as a cold sore virus patient is already stressful enough.
Below are some of the notes from the said academy meeting:
“In subjects with no lesion at baseline, the time to healing was 3.6 days, providing a significant clinical advantage over current topical and systemic agents,” the investigators concluded in a poster presentation.
“The novel physical mechanism of action renders the emergence of drug resistance highly unlikely, making NB-001 an ideal candidate for widespread treatment of common conditions, such as herpes labialis.”
More than 80% of adults have latent herpes simplex virus-1 (HSV-1) in facial ganglia. In one-third of these people, viral reactivation leads to recurrent lesions on the lips and surrounding skin.
Current topical therapies for herpes labialis are largely ineffective, and physicians are reluctant to prescribe oral medication, partly because of concerns about the emergence of drug-resistant strains of HSV-1, the authors said.
NB-001 is an investigational nanoemulsion consisting of high-energy, nanometer-size droplets containing cetylpyridinium chloride, polysorbate, and oil.
When applied to the skin, the droplets enter the epidermis and dermis, but their size prevents entry into epithelial-cell junctions, eliminating the potential for skin irritation or systemic absorption, the investigators continued.
Upon reactivation, latent HSV-1 migrates down nerve endings, existing at the dermal-epidermal junction. At that point, the nanoemulsion droplets surround the virus and fuse with the viral envelope, causing membrane disruption and viral destruction.
Investigators tested NB-001 in 919 adults with a history of HSV-1 reactivation, resulting in an average of three cold-sore outbreaks a year.
Study participants received locked medication kits containing either the NB-001 vehicle or one of three concentrations of the active nanoemulsion (0.1%, 0.3%, and 0.5%).
At the first sign of a recurrence, participants contacted investigators and received a code to unlock the medication kit and apply 200 µL of therapy five times a day for a maximum of five days.
During an outbreak, participants were assessed daily until the lesion healed or was aborted.
A total of 482 participants from 28 sites in the U.S. had cold-sore outbreaks. At the daily assessment during an outbreak, investigators rated the lesion stage as prodrome, erythema, blister, ulcer, scab, or healed. They defined healing as the return of normal skin color and no evidence of scab.
All three formulations of NB-001 led to faster healing of cold sores compared with vehicle, which was associated with a median healing time of 6.0 days and a mean of 6.7 days. However, only the 0.3% concentration significantly reduced healing time (a median of 5.0 days and a mean of 5.4, P=0.0064).
“This treatment effect is higher than that reported for the current topical therapies and is equal to that reported for high-dose oral nucleoside regimens,” the investigators said.
A subset analysis limited to patients who began treatment in the prodromal or erythematous stage showed that patients using the 0.3% nanoemulsion had a mean healing time of 3.6 days, representing about a two-day improvement over vehicle.
The findings supported prior experiments in which the 0.3% emulsion achieved the greatest penetration in cadaver tissue.
No safety issues with the nanoemulsion arose during the study.
Click here for more article on cold sore.
Watch the video related to nanoparticle
Magnetic-materials specialist Kevin O’Grady predicts a big future for magnetic nanoparticles in clinical applications ranging from targeted drug delivery to the heat treatment of cancerous tumours. Kevin O’Grady, professor of physics at the University of York, UK, provides an accessible overview that unpicks the fundamental science of magnetic nanoparticles as well as looking ahead to the delivery of real-world diagnostic and therapeutic nanoparticle technologies for clinical medicine….
Help answer the question about nanoparticle
Is a lot of energy or a vacuum required to move a solid nanoparticle 5 feet as opposed to say an electron?Say it weighs 1, or 999 nanogram.
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Thomas Wong
Now will MagForce allow people with terminal cancer allow be volunteers for testing?
I hear alot about various new cancer treatments but little on it for public use. Also years of red tape delays.
I’m skeptical on when the public will have acess to these treatments.
ouch, how are they going to infect the nanostuff into the HARD tumour in the first place….
Dont want to think about it…
even ones is enough…
It is too early to tell. The newest statement is that the silver used in washing machine systems will be declared a pesticide, which is what they are. Antimicrobials are just pesticides and people have to relize that. Another factor is that under OSHA regs, silver is more regulated (lower PEL) than lead. Noone would add lead to their washing. I think the biggest impact will be on the PR side.
No, not necessarily. Atoms are picometers in size, and nanometers are 1,000 times larger than those. Nanoparticles are clusters of atoms, so there will be a core of atoms packed together.
Assume the particle is spherical, and that atoms are spherical. Work out the volume of the particle, the volume of a gold atom, and from these, the surface area of the particle, and the cross-sectional area of a gold atom. Then check how many gold atom areas will fit on the surface area of the particle.
Refluxing the water is not efficient.
For best production of nanoparticles, use a microwave oven. Check out the modified Lee and Miesel preparation in the publication below:
How does it destroy only the cancer cells?
it depends on how much the nanoparticle weighs. since an electron is 10^-30 kg it requires very little to make it move.
Here are some examples of scaling.
1 meter ~ 1 yard (actually 39.37 inches)
1 mm = one one-thousandth of a meter, approximately 39.37 mils
Micron
1 micron = 1 one-millionth of a meter (um)
diameter of human hair: 17 – 181 um
diameter of red blood cell (erythrocytes): 6 to 8 um
length of a typical bacteria: 0.5 to 5 um
Nanometer
1 nanometer = 1 billionth of a meter (nm)
diameter of shell of a virus: 10 to 300 nm
diameter of DNA helix: 1.84 to 2.55 nm
this treatment doesnt effect areas that the fluid isnt injected in … in case of radiation or chemotherapy many cells outside the tumor are effected
surgery always carries risks
especially on the brain
There may be sufficient raw materials but that's not the issue at this point. Manufacturing costs are too high at this time to mass produce reliable nanoparticle photovoltaic electricity. It just plain costs too much and there isn't a good process ready for mass production right now.
One problem with cancer is that it isn’t one disease, but many. Is this effective against all or most of them?
if this works it would be effective against all types of cancer.
I don’t claim to be a doctor, but it seems that the nano particles are programmed to recognize the cancerous cells. Then it’s just a matter of making them move back and forth destroying the cells. I wonder though what happens if they go to the wrong cells, or if there are leftovers in there. Where do they go?
It’s awsome to see that there are these kinds of things in the works. The potential here is huge, and very exciting.
cancerous cells may perhaps have different absorption ability than normal cells thus only cancerous cells absorbs the nanoparticles. Not sure though. Just a thought.
I’m currently doing with nanomagnetic research project, this video has profoundly give me an insight and lot of information. Thanks for the post
You have all the information you need
Just change your units to be the same (or keep up with them).
I'm assuming the 13nm is given as the diameter… so just divide that by 2 and you have your "r" for the equation. Then fix the units
Density = mass/volume
Rearrange to solve for mass.
Basically, it is tagging the substance to be delivered to an incredibly tiny particle of gold; usually, there is an antibody (or other targeting substance) attached to the gold particle as well, to target a specific cell type or cellular structure. It is the antibody that does the targeting; the gold nanoparticle is but the (essentially passive) tool used to carry the targeting molecule and the drug molecule.
It's one of the developing technologies–it's far from being routine, yet, last I heard.